100 by Wilt Chamberlain vs. the New York Knicks on March 2, 1962

Once thought to be completely unbreakable, Kobe's 81 point effort 2 years ago has made people go "Hmmm....maybe someone could score 100 points in a game." However, if you take Kobe's game away, and factor in Michael Jordan's retirement for the 3rd time, no one has scored more than 70 in nearly 20 years. This record is probably safe unless there are massive rules changes, or David Stern merges the NBA and the WNBA.

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